All the following antimicrobial agents are used topically except –

Griseofulvin is used systemically for dermatophytosis. It is ineffective topically. Polyene Amphotericin B → Topically as well as systemically (oral, iv intrathecally. Nystatin, Hamycin, Natamycin (Pimaricin) → Topically. Hetrocyclic benzofuran Griseofulvin → Systemically (oral) Imidazoles Clotrimazole, econazole, miconozole, oxiconazole → Topical. Ketoconazole Systemically (oral) and topically. Triazoles Fluconazole, voriconazole → systemically (iv., oral) and itraconozole → systemically (orally). Allylamine Terbinafine → Systemically (oral) and topically. Note Amphotericin B, ketoconazole and terbinafine are used systemically as well as topically.