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Unknown General 4a066e00

Which virus is implicated in Burkits lymphoma?

A
EBV
B
HTLV
C
HPV
D
HHV8
High-Yield Explanation
(Refer: Robbins Pathologic Basis of Disease, 8thedition, pg no: 314, 607) Burkitt’s lymphoma There are three clinical types: African (endemic) Burkitt lymphoma. Sporadic (nonendemic) Burkitt lymphoma. Aggressive lymphomas associated with HIV. These 3 types are histologically identical. Immunophenotype These are tumors of mature B cells. It express surface IgM, CD19, CD20, CD10 and BCL6. Molecular Pathogenesis All forms of Burkitt lymphoma are associated with translocationsof the c-MYC gene on chromosome 8. The translocation partner is usually the IgH locus (t(8;14)) butmay also be the Ig k (t(2;8)) or y (t(8;22)) light-chain loci. All endemic tumors are latently infected with EBV, which is alsopresent in about 25% of HIV-associated tumors and 15% to20% of sporadic cases.

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