Thymic hypoplasia is seen in which of the following?
High-Yield Explanation
DiGeorge syndrome/Thymic hypoplasia/Velocardiofacial syndrome T cell deficiency Failure of devt of 3rd & 4th pharyngeal pouches Individuals have Variable loss of T cell mediated immunity - hypolastic thymus Tetany - lack of parathyroids Congenital defects of hea & great vessels T cell zones of lymphoid organs are depleted Deletion of gene mapped to chr 22q11