Mediator of acute inflammation not derived from the cell is:

CHEMICAL MEDIATORS OF INFLAMMATION Aka permeability factors or endogenous mediators of increased vascular permeability. They are broadly classified into 2 groups: i. Mediators released by cells. ii. Mediators originating from plasma. CHEMICAL MEDIATORS OF ACUTE INFLAMMATION A. Cell-Derived Mediators 1. Vasoactive amines Histamine. 5-hydroxytryptamine. Neuropeptides. 2. Arachidonic acid metabolites (Eicosanoids) i. Metabolites via the cyclo-oxygenase pathway Prostaglandins. Thromboxane A2. Prostacyclin. Resolvins. ii. Metabolites via a lipo-oxygenase pathway 5-HETE. Leukotrienes. Lipoxins. 3. Lysosomal components (from PM Ms, macrophages) 4. Platelet-activating factor (PAF) 5. Cytokines IL-1 TNF-α. TNF-β. IFN-γ. Chemokines. 6. Free radicals Oxygen metabolites Nitric oxide B. Plasma-Derived Mediators (Plasma Proteases) Products of: 1. The kinin system. 2. The Clotting system. 3. The Fibrinolytic system. 4. The Complement system.