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Medicine General 49378373

Locus heterogeneity is a feature of which of the following?

A
Familial adenomatous polyposis
B
MENU
C
Osteogenesis imperfecta
D
All of the above
High-Yield Explanation
TYPES OF HETEROGENEITY are A. Allelic Heterogeneity, B. Phenotypic Heterogeneity, C. Locus or Nonallelic Heterogeneity. Nonallelic or locus heterogeneity refers to the situation in which a similar disease phenotype results from mutations at different genetic loci. E.g Osteogenesis imperfecta, Albinism, Muscular dystrophy syndromes (dystrophin, most common cause of mus dystrophy and has large gene size).

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