Risk factors associated with development of Gout all except
High-Yield Explanation
Gout is an inflammatory disease caused by depositionof monosodium urate monohydrate crystals in andaround synol joints. Causes of hyperuricaemia and gout Diminished renal excretion* Increased renal tubular reabsorption** Renal failure* Lead toxicity* Lactic acidosis* Alcohol* Drugs-Thiazide and loop diuretics,Low-dose aspirin,Ciclosporin,Pyrazinamide Increased intake* Red meat* Seafood* Offal Over-production of uric acid* Myeloproliferative and lymphoproliferative disease* Psoriasis* High fructose intake* Glycogen storage disease* Inherited disordersLesch-Nyhan syndrome (HP mutations)Phosphoribosyl pyrophosphate synthetase 1 mutations REF:DAVIDSON'S PRINCIPLES AND PRACTICE OF MEDICINE 22nd EDITION PAGE NO 1087