Pharmacology Anaesthesia 48d3127f Most cardiotoxic local anaesthetic is: A Procaine B Bupivacaine C Prilocaine D Tetracaine High-Yield Explanation - Bupivacaine is most cardiotoxic local anaesthetic - so, it is contra-indicated in intravenous regional anaesthesia (Bier's block) =Prilocaine caused methmoglobinemia