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Microbiology Immunology 48a158a8

Which of the following statements is true about isotypic variation?

A
These result due to subtle amino acid changes resulting from allelic differences
B
These result due to changes in amino acid in heavy and light chain at variable region
C
Changes in heavy and light chain in constant region is responsible for class and subclass of immunoglobulins
D
These are areas in antigen that bind specifically to antibody
High-Yield Explanation
Antibody genes also re-organize in a process called class switching that changes the one type of heavy chain Fc fragment to another, creating a different isotype of the antibody that retains the antigen specific variable region. This allows a single antibody to be used by different types of Fc receptors, expressed on different pas of the immune system. Ref: Ananthanarayan & Parker's textbook of microbiology 9th edition pg: 94

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