Treatment of latent TB infection in Tuberculin positive, HIV positive patients:

Ans. is 'a' i.e., 1NH biweekly for 9 month Dosing regimens for treatment of latent tuberculosis* AdultsChildren <12IsoniazidStandard regimen:o 300 mg PO daily for nine months Alternate regimens:o 300 mg PO daily for six months900 mg PO twice weeklyD for nine months900 mg PO twice weeklyD for six monthsStandard regimen:o 10 to 15 mg/kg PO daily for nine months; not to exceed 300 mg/dayAlternate regimen:o 20 to 30 mg/kg PO twice weekly for nine months; not to exceed 900 mg/dayIsoniazid and rifapentineIsoniazid (orally once weekly for 12 doses, given by direct observation):o 15 mg/kg, rounded up to the nearest 50 or 100 mg; 900 mg maximumRifapentine (orally once weekly for three months, given by direct observation):o 10 to 14 kg: 300 mgo 14.1 to 25 kg: 450 mgo 25.1 to 32 kg: 600 mgo 32.1 to 49.9 kg: 750 mg o >50 kg: 900 mg maximumSee noteYIsoniazid (orally once weekly for 12 doses, given by direct observation):o 15 mg/kg, rounded up to the nearest 50 or 100 mg; 900 mg maximumRifapentine (orally once weekly for three months, given by direct observation):o 10 to 14 kg: 300 mgo 14.1 to 25 kg: 450 mgo 25.1 to 32 kg: 600 mgo 32.1 to 49.9 kg: 750 mgo >50 kg: 900 mg maximumRifampin600 mg PO daily for four months10 to 20 mg/kg PO daily for four months; not to exceed 600 mg/dayIsoniazid and rifampinIsoniazid 300 mg PO daily for three monthsIsoniazid 10 to 15 mg/kg PO daily for three months; not to exceed 300 mg/day Rifampin 600 mg PO daily for three monthsRifampin 10 to 20 mg/kg PO daily for three months; not to exceed 600 mg/day