Pediatrics Endocrinology 488ea7ef Most common brain lesion causing central precocious puberty is: A Tuberculous meningitis B Tuberous sclerosis C Astrocytoma D Hypothalamic hamartoma High-Yield Explanation d. Hypothalamic hamartoma(Ref: Nelson's 20/e p 2658-2659)Hypothalamic hamartomas are the most common brain lesion causing central precocious puberty.