Pseudopolyps are features of -
High-Yield Explanation
Ulcerative colitis
Ulcerative colitis is an inflammatory bowel disease characterized by -
Inflammation involving only the mucosa and submucosa.
Formation of pseudopolyps
Involvement is in a continuous fashion (absent of skip lesions which are characteristic of CD).
Ulcerative colitis involves the rectum and extends proximally in a retrograde fashion to involve the entire colon (pancolitis) in more severe cases.
UC is associated with HLA-DR2, polymorphism in IL-10 gene and an abnormal T-cell response particularly of CD4 T-cells (T H2 cells).