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Pharmacology Anaesthesia 47aaffdb

Pancuronium differs from tubocurarine in that:

A
It is a depolarizing blocker
B
Its action is not reversed by neostigmine
C
It can cause rise in BP on rapid I.V. injection
D
It causes marked histamine release
High-Yield Explanation
* Pancuronium possesses vagolytic activity and can cause hypeension and tachycardia on rapid i.v. injection. * Pancuronium is a competitive NM blocker (Non-depolarizing NM blocker). Its actions can be reversed by anticholinesterases like neostigmine. * Unlike d-TC, histamine release is not seen with pancuronium.

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