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Biochemistry Lipids 47939a6f

In well fed state, the activity of Carnitine Palmitoyl Transferase-1 in outer mitochondrial membrane is inhibited by:

A
Glucose
B
Acetyl-CoA
C
Malonyl-CoA
D
Pyruvate
High-Yield Explanation
Ans. C. Malonyl-CoA(Ref Harper 31/e page 214)Fatty acid oxidation is inhibited in the well fed state because, CPT-I activity is low in fed state because of inhibition by malonyl-CoA, the initial intermediate in fatty acid synthesis formed by acetyl-CoA carboxylase.

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