True about Octreotide:

Octreotide is a synthetic octapeptide with actions similar to somatostatin. Routes of administration: - Intravenous (v. short duration of action) - Subcutaneous - Intramuscular (depot preparation) It is 40 times more potent than somatostatin in suppressing GH secretion. It is being preferred over somatostatin for acro­megaly and secretory diarrheas associated with carcinoid, AIDS, cancer chemotherapy or diabetes. Uses Based on properties of inhibiting secretion of various hormones (GH, TSH, PL, insulin, glucagon), all gi secretions (including gastrin & HCI) and constriction of splanchnic, hepatic and renal blood vessels. Carcinoid and VIP om a induced secretory diarrhea and systemic symptoms such as flushing and wheezing. Diarrhea due to vagotomy and dumping syndrome, short bowel syndrome or AIDS. GI bleeding   Pancreatic fistula, insulinoma, glucagonoma, pancreatic ascites Oncogenic osteomalacia Acromegaly Adverse effects: Abdominal pain, nausea, steatorrhoea, diarrhea, gall stones.