Pathology Breast 464cf8f0

B6. Following is not true about the gene mutations leading to breast carcinoma

Most common mutation in inherited breast carcinoma is BRCA1

BRCA 1 mutation is present in most of the cases of breast carcinoma

Inherited breast carcinomas make about 3 % of the total cases

p53 mutation also increases chances of colon and brain cancer

High-Yield Explanation

Ans. (b) BRCA 1 mutation is present in most of the cases of breast carcinoma(Ref: Robbins 9th/pg 1054; 8th/pg 1077)a. Most common gene involved in familial breast cancer-BRCA1(52%) > BRCA1(32%)b. p53 mutation is present in most of the cases of breast carcinomac. Inherited breast carcinomas make about 3 % of the total casesd. p53 mutation increases risk of all cancers

B6. Following is not true about the gene mutations leading to breast carcinoma

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