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Pathology Genetics 4608c5f0

Increasing severity of mental retardation of male members over generations is a result of -

A
Mitochondrial DNA mutation
B
Frameshift mutation
C
Y linked disorder
D
Trinucleotide repeat mutation
High-Yield Explanation
Ans. (d) Trinucleotide repeat mutation(Ref: Robbins 9th/pg 168-171; 8th/pg 168-171)Increasing severity of mental retardation of male members over generations is a result of "anticipation", seen in disorders caused by Trinucleotide repeat mutation. Eg Fragile X syndrome

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