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Medicine General 46020c7b

All of the following are used for treatment of stiff person syndrome, EXCEPT:

A
Diazepam
B
Valproate
C
IV Ig
D
None of the above
High-Yield Explanation
Optimal treatment of stiff-person syndrome requires therapy of the underlying tumor, glucocoicoids, and symptomatic use of drugs that enhance GABA-ergic transmission (diazepam, baclofen, sodium valproate, tiagabine, vigabatrin). A benefit of IVIg has been demonstrated for the nonparaneoplastic disorder but remains to be established for the paraneoplastic syndrome. Ref: Harrison's principle of internal medicine 17th edition, chapter 97

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