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Surgery Transplantation 44545c4a

Which of the following is true regarding successful whole- organ pancreas transplantation in type I diabetes?

A
It results in maintenance of normal serum glucose levels
B
Recurrence of diabetic nephropathy in simultaneously transplanted kidneys is not prevented
C
Oral glucose tolerance tests remain abnormal
D
The pathologic changes of diabetic retinopathy are reversed
High-Yield Explanation
Whole-organ pancreas transplantation is the only therapy for type I insulin-dependent diabetes that maintains normal serum glucose levels and normal glucose tolerance tests. When the pancreas is transplanted along with a kidney, the tight glucose control generally prevents the recurrence of diabetic nephropathy. No series has shown the reversal of diabetic retinopathy or reduction in the rate of diabetic ulcers or of amputations, although some parameters of diabetic retinopathy may improve after pancreas transplantation.

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