Which one of the following is not true regarding Centchroman ?

Ans. is c i.e. It is a synthetic hormone Centchroman : It is a synthetic NON-STEROIDAL (ormiloxifene) contraceptive. A tablet of 30 mg staed on 1st day of menstruation and taken twice weekly for 12 weeks, and weekly thereafter (t1/2 - 170 hrs). Mechanism of action : - it prevents implantation through endometrial changes and does not inhibit ovulation. - increases transpo of zygote through the fallopian tube. - It accelerates blastocyst formation. Developed by CDRI, Lucknow and released in India by 2 trade names Saheli and Centron. Exhibits strong anti-estrogenic and a weak estrogenic actions peripherally at receptor level. It is not teratogenic or carcinogenic, exes no pharmacological effect on other organs. The only side effect noted is prolonged cycles and oligomenorrhea in 8% cases. This is due to prolonged proliferative cases. Pregnancy rate is (1-4 )/100 women years. Return of feility is within 6 months of stopping the drug. The drug can also be used as a post coital pill, given in 60 mg dose within 24 hours of coitus, 2 tablets repeated after 12 hours with a failure rate of 1%. Side effects - headache, nausea, vomiting, gain in weight, does not protect against HIV and STD, Prolonged cycles (due to prolonged proliferative phase) and oligomenorrhea (in 8% cases). There is some delay in return of feility. Contraindications : During first 6 months of lactation PCOD, hepatic dysfunction, Kidney disease, TB Non-Contraceptive use : Because of its potent anti estrogenic activity - It is being tried in : DUB Endometrial hyperplasia Endometriosis Breast cancer It is used as H because of its weak estrogenic propey