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Pathology Hypersensitivity 44079503

Which of the following is not a feature of bronchial asthma?

A
Thickening of bronchial wall
B
Increase in number of airway goblet cells
C
Fibroblastic foci
D
Sub-basement membrane fibrosis
High-Yield Explanation
Fibroblastic foci (exuberant proliferation of fibroblasts) is a feature of idiopathic pulmonary fibrosis (IPF). Bronchial asthma is an example of Type I Hypersensitivity reaction and is characterised by airway remodeling which includes: Thickening of bronchial wall with hyperophy and/or hyperplasia of bronchial smooth muscles Increase in size of submucosal glands and number of goblet cells Increased vascularity Sub-basement membrane fibrosis (due to deposition of type I and III collagens) Key points - Sputum findings in bronchial asthma: Curshmann spirals - impacted mucin plugs Charcot Leyden crystals - Eosinophil crushing aefact Creola bodies - damaged respiratory epithelial cells

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