Protein synthesis in eukaryotes is different from prokaryotes. Which of the following is NOT TRUE about steps in initiation of eukaryotic protein synthesis?
High-Yield Explanation
Initiation of protein synthesis can be divided into four steps: Dissociation of the ribosome into its 40S and 60S subunits; Binding of a ternary complex consisting of the initiator methionyl-tRNA, (met-tRNAi), GTP, and eIF-2 to the 40S ribosome to form the 43S preinitiation complex; Binding of mRNA to the 40S preinitiation complex to form the 48S initiation complex; and Combination of the 48S initiation complex with the 60S ribosomal subunit to form the 80S initiation complex. Ref: Weil P. (2011). Chapter 37. Protein Synthesis & the Genetic Code. In D.A. Bender, K.M. Botham, P.A. Weil, P.J. Kennelly, R.K. Murray, V.W. Rodwell (Eds), Harper's Illustrated Biochemistry, 29e.