A 50-year-old patient's pH- 7.05, HCO3=5 PCO2=12, BE=30 mEq/L. How much sodium bicarbonate to be given in first hour?

Ans. a. 100Bicarbonate deficit can be calculated as follows:1st method by formula:HCO3- deficit=0.5xbody weight in kgx(24-HCO3- )Half of the calculated deficit should be administered within the first 3-4 hours to avoid overcorrection and volume overload.2nd method: In general, severe acidosis (pH<7.10) warrants the IV administration of 50-100 mEq of NaHCO3 , over 30-45 min, during the initial 1-2 hours of therapy.