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Pediatrics General 43769ae4

In thromboasthenia there is a defect in –

A
Platelet aggregation
B
Platelet adhesion
C
Decreased ADP release
D
Desordered platelet secretion
High-Yield Explanation
Platelet adhesion Platelet adhesion referes to the binding of platelets to subendothelial matrix. Platelet membrane glycoprotein Ib-IX is essential for platelet adhesion to subendothelial matrix. Platelet aggregation Platelet aggregation referres to adherence of platelets to one another. Platelet membrane glycoprotein ddb-IIIa helps in aggregation. Congenital dysfunction of platelet 1. Bernard-soulier syndrome Defect in platelet adhesion due to inherited deficiency of glycoprotein Ib-IX. 2. Glanzmann's thrombasthenia Defect in platelet aggregation due to inherited deficiency of glycoprotein Ilb-IIIa.

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