Fluconazole differs from ketoconazole in that:

Fluconazole does not have anti-androgenic side effects. Ketoconazole is rarely used now a days because of several limitations like: Poor oral bioavailability Limited CNS penetration Powerful inhibition of microsomal enzymes Used in treatment of Cushing Syndrome Anti-androgenic adverse effects like gynaecomastia Fluconazole is preferred agent because it has: Very good oral absorption Maximum CNS penetration (therefore effective in cryptococcal meningitis). No inhibitory action on microsomal enzymes No anti-androgenic propey.