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Pharmacology Chemotherapy: General Principles 431c0c74

Which of the following parameters is not monitored in a patient on methotrexate therapy?

A
Liver function tests
B
Lung function test
C
Eye examination
D
Hemogramz
High-Yield Explanation
Ans. (C) Eye examination(Ref: CMDT 2010, 1501)Methotrexate toxicities include:MyelosuppressionNephrotoxicityHepatotoxicityNeurotoxicity (with intrathecal administration and high-dose therapy)PhotosensitivityPulmonary toxicityMultiple drug interactions which may enhance toxicities (avoid aspirin, penicillins, NSAIDs, omeprazole, TMP-SMZ)

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