Which of the following syndromes is best associated with congenital hea disease -

Ans. is 'c' i.e., Holt Oram Syndrome "The strongest familial tendency is known in ASD associated with bony abnormalties (Holt-oram syndrome)" Genetics of Congenital hea disease Syndrome Associated Cardiovascular diseases ASD Ist degree hea block Holt oram Syndrome (absence of radius hypoplastic thumb hypoplastic clavicle) Trisomy 21 ASD, VSD, TOF Noonan Syndrome PS, ASD, hyperophic cardiomyopathy William Syndrome Supravalvular, AS, Branch PS, hypercalcemia Marfan Syndrome Aoic root dilatation, (A.R.) Familial ASD with hea block Right sided cardiac lesions. Alagille syndrome (Bile duct hypoplasia) Char syndrome PDA, Craniofacial limb defects. Turner syndrome Coarctation of Aoa, Bicuspid Aoic valve Edward Syndrome VSD, PDA Romanowand Syndrome Long QT Conradi - Hunermann VSD, PDA Ape Syndrome VSD Cridu chat Syndrome VSD Osteogenesis imperfecta AR