Treatment of multiple carboxylase deficiency –

Pathogenesis of multiple carboxylase deficiency Deficiency of either holocarboxylase synthase or biotinidase impaires biotin metabolism. Biotin is a cofactor for various carboxylases in the body - Impaired metabolism of biotin results in multiple carboxylase deficiency. So, for the treatment of multiple carboxylase deficiency, biotin should be given.