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Medicine General 4303aad9

All of the following are associated with hypergonadotrophic hypogonadism in males, EXCEPT:

A
Viral orchitis
B
Klinefelter's syndrome
C
Kallman's syndrome
D
Noonan syndrome
High-Yield Explanation
Kallman's syndrome is associated with hypogonadotropic hypogonadism resulting in decreased or absent GnRHsecretion. This syndrome is characterized clinically by anosmia, hypogonadism and other midline defects (cleft lip/palate, colour blindness, seizures, anosmia etc). This syndrome is due to impaired migration of GnRH releasing neurons to hypothalamus during the embryonic period. Ref: Cancer and Sexual Health By John P. Mulhall page 197; Organic psychiatry: the psychological consequences of cerebral disorder By William Alwyn Lishman page 526; Manual of Endocrinology and Metabolism By Norman Lavin page 292; The immunoassay handbook By David Wild page 567

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