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Pharmacology Endocrinology 42f7454d

Hypospadias in the baby is caused by maternal use of which of the following drug?

A
Diethylstilbestrol
B
Tolbutamide
C
Clomiphene
D
Clobazam
High-Yield Explanation
Clomiphene is antiestrogens. It can cause hypospadias in the baby- in which the opening of the urethra is on the underside of the penis instead of at the tip Clomiphene, a drug used to induce ovulation, is chemically related to diethylstilbestrol (DES). DES is associated with vaginal adenocarcinoma among daughters and with hypospadias among second-generation male offspring. (REF. Essentials of medical pharmacology K D TRIPATHI 6 Edition, Page No 312)

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