Pathology Misc. (R.B.C) 42d42c58 Most common mutation in hereditary spherocytosis A Spectrin B Ankyrin C Glycophorin A D Band 3 High-Yield Explanation Ans. (b) Ankyrin(Ref: Robbins 9th/pg 632; 8th/pg 642)Most common mutation:Hereditary spherocytosis is Ankyrin>Band-3>spectrinHereditary elliptocytosis is Spectrin