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Pharmacology General Pharmacology 4211e201

Percentage of drug existing as enantiomer is:

A
<1%
B
10%
C
>50%
D
100%
High-Yield Explanation
Ans: c (>50%) Ref: Katzung, 10 ed, p. 4Due to chirality (stereoisomerism) more than half of all useful drugs exists as enantiomers.Other important properties:One of the enantiomers will be more potent than its mirror image. The potent enantiomer which is active at one type of receptor may not be active at another type.One of the enantiomers will be more susceptible to drug metabolizing enzymes than the other.

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