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Medicine Kidney 418f69be

Membranous glomerulonephritis is associated with-

A
Renal Venous thrombosis
B
Hodgkin's disease
C
Subepithelial immune deposits
D
Hematuria
High-Yield Explanation
Membranous nephropathy Membranous nephropathy is the most common cause of nephrotic syndrome in Caucasian adults. It is caused by antibodies (usually autoantibodies) directed at antigen(s) and venous thrombosis Antigens expressed on the surface of the podocytes, including the M-type phospholipase A2 receptor 1. While most cases are idiopathic, a propoion are associated with other causes, such as heavy metal poisoning, drugs, infections, lupus and tumours . Approximately one-third of patients with idiopathic membranous nephropathy undergo spontaneous remission, one-third remain in a nephrotic state, and one-third develop progressive CKD. High doses of glucocoicoids and cyclophosphamide may improve both the nephrotic syndrome and the long-term prognosis. However, because of the toxicity of these regimens, many nephrologists reserve such treatment for those with severe nephrotic syndrome or deteriorating renal function. Treatment of secondary membranous nephropathy is directed at the underlying cause. Ref Harrison20th edition pg 266

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