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Pathology General 41712332

All the following conditions cause thrombocytopenia except -

A
Giant hemangioma
B
Infectious mononucleosis
C
HIV infection
D
Iron deficiency anemia
High-Yield Explanation
CAUSES OF THROMBOCYTOPENIA DECREASED PRODUCTION OF PLATELETS Selective impairment of platelet production Drug-induced: alcohol, thiazides, cytotoxic drugs Infections: measles, human immunodeficiency virus (HIV) Nutritional deficiencies B12, folate deficiency (megaloblastic anemia) Bone marrow failure Aplastic anemia Bone marrow replacement Leukaemia, disseminated cancer, granulomatous disease Ineffective hematopoiesis Myelodysplastic Syndromes DECREASED PLATELET SURVIVAL Immunologic destruction Primary autoimmune Chronic immune thrombocytopenic purpura Acute immune thrombocytopenic purpura Secondary autoimmune  SLE, B cell lymphoid neoplasms Alloimmune : post-transfusion and neonatal Drug-associated: quinidine, heparin, sulfa compounds Infections: HIV, infectious mononucleosis (transient, mild), dengue fever Non-immunologic destruction Disseminated intravascular coagulation Thrombotic microangiopathies Giant hemangiomas SEQUESTRATION Hypersplenism DILUTION Transfusion

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