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Pathology General 41251920

Which is not true regarding coeliac disease -

A
Total and sub-total villous atrophy
B
Increased chance of lymphoma
C
Anti-gliadin antibody persists even after gluten free diet
D
↑disacharidases
High-Yield Explanation
In coeliac sprue : Total or subtotal villous atrophy   Increased chance of lymphoma Association with dermatitis herpetiformis Antigliadin antibody Secondary lactase deficiency No mucosal atrophy Lymphocytes in lamina propria Following information have been added to 8th/e of Robbins The most sensitive non-invasive serological tests are the presence of IgA antibodies to tissue transglutaminase or IgA/IgG antibodies to deamidated gliadin. Anti-endomysial antibodies are highly specific but less sensitive.

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