Fibroblast is derived from-

o Fibroblasts produce the glycosaminoglycans, collagens, elastic fibers, reticular fibres and glycoproteins that can be seen in the extracellular matrix. They also produce cytokineTSLP. o Fibroblasts are originally derived from primitive mesenchyme and therefore display the filament protein vimentin, which acts as a marker of mesodermal origin. o Inactive fibroblasts are called fibrocytes. When tissue damage has occurred, the fibrocytes are stimulated to undergo mitosis or multiplication by replication and division. o Transforming growth factor P induces proliferation offibroblasts. It is chemotactic for fibroblasts