Which one of the following is not a feature of liver histology in Non-cirrhotic portal fibrosis (NCPF)?
High-Yield Explanation
Fibrosis in noncirrhotic portal fibrosis is confined to portal and periportal region.
Fibrosis bridging one portal tract to another (bridging fibrosis) is not seen.
Pathology :
Non-cirrhotic portal fibrosis is primarily a vascular disorder of the liver characterized by fibrous intimal thickening of the portal vein or its branches in patients with non-cirrhotic portal hypertension.
Vascular changes
Hallmark of the disease is thrombosis/sclerosis of the portal vein branches.
The portal vein is dilated with sclerosis of the walls and in autopsy thrombin, in medium or small portal vein branches with accompanying areas of ischaemic necrosis have been reported.
Aberrant Intrahepatic vessels may be present in the periportal area, which correspond to dilated terminal portal vein branches or venues. These are often termed as "megasinusuoids" or periportal angiomatosis.
Fibrosis
Vascular changes are accompanied by the portal and periportal fibrosis of varying extent.