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Pathology AIIMS 2019 40a69530

Iron entry into enterocytes occurs which of the following?

A
DMT-1
B
Ferropoin
C
Transferrin
D
Hepcidin
High-Yield Explanation
GI Luminal non-heme iron is mostly in the Fe3+ (ferric) state and must first be reduced to Fe2+ ferrous) iron by ferrireductases, such as b cytochromes and STEAP3. Fe2+ iron is then transpoed across the apical membrane of enterocytes by divalent metal transpoer-1 (DMT1).

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