In which of the following vegetation are friable and easily detachable from the cardiac valves

Infective endocarditis is a serious infection mandating promt diagnosis and intervention. Microbial invasion of hea valves or mural endocardium often with destruction of the underlying cardiac tissue characteristically results in bulky , friable vegetation composed of necrotic debris, thrombus, and organisms. The aoa , aneurysmal sacs , other blood vessels and prosthetic devices also can be affected. Robbins 9 th edition page no. 393