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Pathology General 400304d8

A 20 year old female was diagnosed with granulose cell tumor of the ovary. Which of the following bio markers would be most useful for follow-up of patient?

A
Inhibin
B
CA50
C
CA 19-9
D
Neuron – specific enolase
High-Yield Explanation
Granulosa cell tumor • The most common type of ovarian tumor that is composed of cells that stain positively with inhibin. • Histologically, the cells may form Call-Exner bodies • The tumor cells may secrete estrogens and cause precocious sexual development in girls or increase the risk for endometrial hyperplasia and carcinoma in women. • Less commonly granulosa cell tumors can secrete androgens and produce masculinization.

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