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Gynaecology & Obstetrics Medical & Surgical Illness Complication Pregnancy 3fd702e4

A pregnant mother is treated with oral anticoagulant. The likely congenital malformation that may result in the fetus is:

A
Long bones limb defect
B
Cranial malformation
C
Cardiovascular malformation
D
Chondrodysplasia punctata
High-Yield Explanation
Ans. is d, i.e. Chondrodysplasia punctateRef. Dutta Obs. 7/e, p 511Warfarin is an anticoagulant drug.Action: Interferes with the synthesis of the vitamin K dependent factors like II, VII, IX and X.Side effects:HemorrhageIt leads to:-Contradi's syndrome: skeletal and facial anomalies in the fetus-Chondrodysplasia punctata in the fetus.Miscarriage, IUGR and stillbirths accentuates neonatal hypothrombinemia.

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