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Pharmacology General 3f414e9c

Mention the true/false statements about digoxin toxicity?

A
The earliest manifestation of digoxin toxicity are gastrointestinal symptoms
B
Non-specific vision changes may be noted in digoxin toxicity
C
Early toxicity may not correlate with serum levels and Neurological symptoms may occur without corresponding cardiovascular changes
D
All
High-Yield Explanation
Ans. All are true about digoxin toxicity.DIGOXIN TOXICITY:Features:Generally unwell & lethargy.Nausea & vomiting.Confusion.Yellow-green vision.Arrhythmias (e.g. AV block, bradycardia)Dizziness.Precipitating factors:Renal disease HypokalaemiaHypomagnesemia HypoalbuminemiaHypothermiaHypothyroidismHypercalcemia.HypernatremiaAcidosis.Myocardial ischemia.Paial AV block.Drugs:Amiodarone.Quinidine.Verapamil.Spironolactone.Furosemide.Hydrochlorothiazide - Compete with DCT secretion, hence reducing excretion.ManagementDigibind.Correct ventricular arrhythmia by lignocaine.Bradyarrhythmias by propanolol.Atrial tachyarrhythmias by atropine.Phenytoin.Monitor K+

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