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Pharmacology Cardiovascular system 3f2f0ec1

Mechanism of action of sodium nitrate in cyanide poisoning is

A
Produces methamoglobinemia
B
Increased blood flow to liver
C
Increased blood flow to hea
D
Increased blood flow to kidney
High-Yield Explanation
Sodium nitroprusside contain 1 Iron molecule coordinated to five cyanide molecules and one molecule of nitric oxide Prolonged use of Sodium nitroprusside may cause cyanide poisoning Detoxification occurs when cyanide and methamoglobin combines to form cyanomethamoglobin. Amyl nitrate and sodium nitrates enhance the oxidation of hemoglobin to methamoglobin, ensuring reliable mechanism of detoxification Refer kDT 6/e p 527

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