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Pathology General 3f237d01

Which of the following are chemokines?

A
IL-8
B
Leukotriene A4
C
C5
D
C3
High-Yield Explanation
Their name is derived from their ability to induce directed chemotaxis in nearby responsive cells; they are chemotactic cytokines C-X-C OR ALPHA CHEMOKINE a. CXC chemokines specifically induce the migration of neutrophils b. Secreted by activated macrophage t endothelial cell and other cell c. Includes IL-8 C-C OR BETA CHEMOKINE: a. induce chemotaxis of monocytes, eosinophils, lymphocytes but not neutrophils b. Includes I. Monocyte chemoattractant protein ( MCP-1) II. Eotaxin III. Macrophage inflammatory protein ( MIP) IV. RANTES C-CHEMOKINE OR GAMMA CHEMOKINES a. Relatively specific for lymphocyte b. Include lymphotactin CXC CHEMOKINE a. Two forms I. Cell surface-bound II. Soluble b. Include fractalkine

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