The toxic princple of this plant is:-

Mayapple (May Apple) Other Common Names: American Mandrake. Toxic Principle : Podophyllin (purified form: podophyllotoxin): Clinical Features 1. Exposure of eyes to podophyllum powder causes intenseirritation with conjunctivitis, keratitis, corneal ulceration, and iritis. 2. Ingestion results in nausea, abdominal pain, vomiting,and diarrhoea, followed by fever, tachypnoea, peripheral neuropathy, tachycardia, hypotension, ataxia, dizziness,lethargy, confusion, and altered sensorium.