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Pharmacology Anticoagulants and Coagulants 3f079077

Vitamin K is a cofactor in:

A
Carboxylation
B
Hydroxylation
C
Deamination
D
Hydrolysis
High-Yield Explanation
Ans. (A) Carboxylation(Ref: Katzung 10/e p549, 550; KDT 8/e p667)Vitamin K is involved in activation of various clotting factors (like II, VII, IX and X) as well as anti-clotting proteins (like protein C and S). It carries out the final step in activation of these factors i.e. gamma carboxylation of glutamate residues in these factors.

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