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Pharmacology General 3f02aa5a

Which of the following is the primary mechanism of action of fluoride on topical application?

A
Forming a reservoir in saliva
B
Inhibition of plaque bacteria
C
Improvement in tooth morphology
D
Conversion of hydroxyapatite to fluorapatite by replacing the OH- ions
High-Yield Explanation
The presence of fluoride reduces the solubility of enamel by promoting the precipitation of hydroxyapatite and phosphate mineral. Ca10(P04)6(OH)2 +2F- -> Ca10(PO4)6F2 + 2OH (OH ions are replaced) (hydroxy-apatite) (fluro-apatite) Ref: Essentials of Pedodontics By Tilakraj, Pages 182-3 ; A Textbook of Public Health Dentistry By Marya, Page 348

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