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Pharmacology JIPMER 2017 3ef86127

Table sugar can be used for treatment of hypoglycaemia secondary to all of the following drugs EXCEPT:

A
Acarbose
B
Metformin
C
Glipizide
D
Insulin
High-Yield Explanation
Acarbose: Alpha glucosidase inhibitor, stops the conversion of sucrose to glucose. Therefore using table sugar for treatment of hypoglycemia when patient is on acarbose is not useful. MOA: Located in the intestinal brush border, a-glucosidase enzymes break down carbohydrates into glucose and other simple sugars that can be absorbed. Acarbose and miglitol reversibly inhibit a-glucosidase enzymes. Major s/e are flatulence, diarrhea and abdominal cramping.

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