Cell surface molecules involved in peripheral tolerance induction are

Immunological tolerance in peripheral lymphoid organs is called as peripheral tolerance. It requires signal to (interaction between CD28 and B7). CD28 molecules (co-stimulatory molecule) bind to their ligands-CD80 (B7-l) and/or CD86 (B7-2) and activates T-cell. If the antigen presented by cell do not bear CD28 ligand, a negative signal is delivered and cell become tolerant and anergic.