Pharmacology Pharmacokinetics 3e44122b

True statement about weakly basic drugs is:

These are bound primarily to plasma albumin

These are excreted faster in acidic urine

Are highly ionized in the intestinal juice

These are absorbed mainly from stomach

High-Yield Explanation

Acidic drugs bind to plasma albumin whereas basic drugs to alpha-1 acid glycoprotein. Acidic drugs are excreted faster in alkaline urine whereas basic drugs in acidic urine. Acidic drugs are ionized in alkaline medium (as in intestine) whereas basic drugs are ionized in acidic medium (as in stomach) Non-ionized drugs can cross the membrane and can be absorbed.

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