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Pharmacology Endocrinology 3e05b2d0

Mechanism of aspirin action is

A
Conves inactive plasminogen into active plasmin
B
Inhibits COX and thus thromboxane synthesis
C
Enhances the interaction between antitrombin III and both thrombin and the factors involved in the intrinsic clotting cascade
D
Inhibits the glycoprotein IIb/IIIa complex
High-Yield Explanation
Aspirin inhibits the synthesis of thromboxane A2 by irreversible acetylation of the enzyme cyclooxygenase.Other salicylates and nonsteroidal anti-inflammatory drugs also inhibit cyclooxygenase but have a shoer duration of inhibitory action because they cannot acetylate cyclooxygenase; that is, their action is reversible.Katzung 13e pg: 595
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